Centrilobular hepatocellular hypertrophy
WebLOAEL is 250 ppm (equivalent to 29/38mg/kg/ day [M/F]), based on minimal to moderate centrilobular hepatocellular hypertrophy, minimal to severe extramedullary hematopoiesis, minimal to moderate pigment deposition in the sternal bone marrow, and increased incidence of tissue masses/nodules in the lungs in the males, and minimal to … WebThere was a volume-related induction of hepatic CYP 1A1/2, 2B1/2 and/or 2E1 subfamilies from 5 mL/kg/day, with high liver weight, centrilobular hepatocellular hypertrophy and high ALT, triglyceride and cholesterol serum values at 20 mL/kg/day.
Centrilobular hepatocellular hypertrophy
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WebJan 13, 2014 · The patches of necrosis (see Figure 8, bottom center) are hypereosinophilic, and the fatty change is centrilobular with extension well into midlobular areas. Figure 9 and Figure 10 represent a diagnosis of … WebResults Repeated oral administration of the Platycodi radix water extract to rats resulted in an increased incidence of centrilobular hepatocellular hypertrophy in the liver, diffuse follicular...
WebCentrilobular hepatocellular hypertrophy was observed in exposed male and female rats. Unidentified yellow-brown pigment granules were present in hepatocytes and renal … WebTranslations in context of "hepatocelulară" in Romanian-English from Reverso Context: Hipertrofia centrolobulară hepatocelulară a fost în concordanţă cu inducţia enzimatică specifică rozătoarelor.
WebJul 15, 2006 · Treatment of CD1 mice with 0, 20, 60, 180 or 1300 ppm fenbuconazole for up to 4 weeks caused a dose-dependent increase in liver weight that was associated with centrilobular hepatocellular hypertrophy, cytoplasmic eosinophilia and panlobular hepatocellular vacuolation, as well as an initial increase in the cell proliferation labeling … WebPure pentachlorophenol exists as colorless crystals that are poorly soluble in water, but dissolve in organic solvents such as alcohol, ether, and benzene. Typically, technical-grade pentachlorophenol is 86–90% pure. Contaminants generally consist of other polychlorinated phenols, chlorinated dibenzo-p-dioxins (CDDs), and chlorinated dibenzofurans (CDFs), …
WebK (+)PFHxS-induced effects noted in parental males included: (1) at all doses, reductions in serum total cholesterol; (2) at 0.3, 3, and 10mg/kg-d, decreased prothrombin time; (3) at 3 and 10mg/kg-d, increased liver-to-body weight and liver-to-brain weight ratios, centrilobular hepatocellular hypertrophy, hyperplasia of thyroid follicular cells, …
WebTranslations in context of "modérée ainsi" in French-English from Reverso Context: On peut également déceler une anémie modérée ainsi qu'une augmentation du nombre de globules blancs. tribophotonicsWebIn the case of hepatocellular hypertrophy accompanied by the induction of drug-metabolism related proteins, hypertrophy often starts to be observed in the … tribo oxidationWebhepatic lobule but is more prominent in the centrilobular areas. The increase in nuclear size is consistent with polyploidy, but in this subchronic study, the severity is significantly … tribooxWebJul 17, 2024 · The severity of centrilobular hepatocellular hypertrophy observed in histopathology ranged from minimal to mild in affected rats and this change was determined to be an adaptive response to increased hepatic metabolic activities associated with the treatment [33, 34]. Hence, all of these treatment-related changes were concluded to be … tribophysicsWebMar 29, 2024 · Hepatocellular hypertrophy is frequently seen in the liver following exposure to agents that cause hepatic enzyme induction. The hypertrophy typically starts in the centrilobular area and extends to the … tri bootsWebSAGE Journals: Your gateway to world-class research journals triboo tileWebNov 12, 2004 · hepatocellular hypertrophy in both sexes; and an increased incidence of slight focal hepatic necrosis in females. Table 4 Subchronic, Chronic, and Other Toxicity Profile ... males; increased centrilobular hepatocellular hypertrophy in females 870.4100b Chronic toxicity dogs (Beagle) 46454110 (2004) Acceptable/Guideline 0, 10, … terelion brownsville tx