Glut2 obesity
WebFeb 1, 2024 · GLUT2 is localized at the basolateral membrane and transports glucose and fructose out of the cells into the bloodstream [13, 14]. GLUT1 has lateral and intracellular … WebNov 13, 2013 · GLUT2 mRNA was decreased by incubation with berry extract in a time- and dose-dependent manner . Furthermore, GLUT2 protein levels were lower in cells exposed to berry extract (0.125% (w/v)) for 16 h ... In the long term these events are risk factors for obesity and type 2 diabetes. Thus strategies which modulate apical GLUT2 expression …
Glut2 obesity
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WebMay 29, 2024 · Significantly increased expression of intestinal sugar transporters (SGLT1, GLUT2, and GLUT5) has been observed in different animal models of obesity and/or diabetes [20, 21, 22]. Interestingly, studies in humans indicate heterogeneous expression [23] and cellular distribution of these major sugar transporters in obesity. WebPermanent apical GLUT2, resulting in increased sugar absorption, is a characteristic of experimental diabetes and of insulin-resistant states induced by fructose and fat. The nutritional consequences of apical and basolateral GLUT2 regulation are discussed in the context of Western diet, processed foods containing artificial sweeteners, obesity ...
WebFeb 12, 2024 · Data suggest that high fat diet-induced obesity is associated with elevated intestinal maltase activity, GLUT2 expression, and permanent apical GLUT2 in the small intestinal mucosa of rats, and that octreotide can inhibit these effects. Hexose transporter-mediated glucose uptake was greater in duodenum and jejunum compared with ileum. WebDec 1, 2024 · Hepatic gain of IDE function changes the ratio GLUT1/GLUT2 in HFD-induced obesity. (A) Representative immunoblot using anti-GLUT2 and anti-GLUT1 antibodies. Expression of GAPDH was determined to ensure similar protein levels for total liver lysates. Densitometric quantification of GLUT2 (B) and GLUT1 (C).
WebJun 1, 2024 · Here, we determined whether loss of Glut2 (also known as Slc2a2) specifically in the kidneys would reverse hyperglycaemia and normalise body weight in mouse models of diabetes and obesity. WebFeb 26, 2014 · Introduction. The worldwide increase in obesity and diabetes mellitus type 2 has brought new interest to the mechanisms by which dietary monosaccharides are absorbed in the intestine and to which extent these systems undergo diet-dependent regulation. Glucose derived either from hydrolysis of starch or from sucrose is taken up …
WebKeywords: GLUT2, PEPCK, G6Pase, phlorizin, NASH. Introduction. ... Despite the different obesity degrees, both T2D and HF-T2D mice showed similar metabolic-hormonal alterations , such as significant increases in plasma glucose, insulin and triglycerides. Furthermore, T2D and HF-T2D presented very high indexes of HOMA-IR and decreased …
WebPermanent apical GLUT2, resulting in increased sugar absorption, is a characteristic of experimental diabetes and of insulin-resistant states induced by fructose and fat. The … lexmark mc3300 series hbp printerWebApr 1, 2006 · The higher daily food intake of ripglut1;glut2 −/− mice could have been expected to cause obesity, which was, however, not the case. Preliminary experiments indicated that preservation of a normal body weight could not be explained by an increase in energy expenditure or by an increase in locomotor activity. lexmark mc2535 toner replacementWebNov 20, 2024 · Obesity and type-2 diabetes trends continue to worsen in the United States. Dietary anthocyanins (typically provided by berries and other fruits) are reported to have protective effects against both conditions using a variety of experimental research models including animal and human feeding studies. This review highlights studies that explore … mccrite kansas cityWebApr 1, 2006 · The higher daily food intake of ripglut1;glut2 −/− mice could have been expected to cause obesity, which was, however, not the case. Preliminary experiments … lexmark mc3200 series hbp tonerWebObesity-related insulin resistance is a highly prevalent and growing health concern, which places stress on the pancreatic islets of Langerhans by increasing insulin secretion to lower blood glucose levels. The glucose transporters GLUT1 and GLUT3 play a key role in glucose-stimulated insulin secretion in human islets, while GLUT2 is the key isoform in … lexmark mc3224i driver for windows 10WebMar 8, 2024 · Deletion of the glucose transporter GLUT2 altered sensitivity to chemically induced epithelial permeability and protected mice from pathogen invasion. ... Obesity is associated with intestinal ... mcc rock solid facebookWebAug 1, 1995 · It is proposed that in uncomplicated obesity, increased lipid availability (FFA levels <1.5 mmol/1) induces both hyperinsulinemia and insulin resistance in parallel fashion, thereby maintaining normoglycemia. A further increase in substrate overload impairs β-cell compensation for insulin resistance and hyperglycemia appears. lexmark mc3224 wireless setup