2024 Gwas sleep duration

Gwas sleep duration

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WebJan 27, 2024 · We conducted a genome-wide association study (GWAS) of sleep health score (overall assessment of sleep duration, snoring, insomnia, chronotype, and daytime dozing) using 336,463 participants from the UK Biobank. Proteome-wide association study (PWAS) and transcriptome-wide association study (TWAS) were then performed to … WebApr 11, 2024 · The mission of the Public Health Genomics is to integrate advances in human genetics into public health research, policy, and programs

Genome-wide association analyses of sleep …

WebAug 2, 2024 · Background Alzheimer's disease (AD) is the most frequently occurring type of dementia. Concurrently, inadequate sleep has been recognized as a public health epidemic. Notably, genetic and environmental factors are now considered contributors to AD progression. Objective To assess the association between sleep duration, genetic … WebThe results showed that a total of 15 and 37 QTLs were detected from SNP and haplotype-based GWAS, respectively. Among them, seven QTL clusters were identified by haplotype-based GWAS. ... Opportune flowering time is crucial for survival in specific environments and regulates life-cycle duration, yield, seed quality, resistance to diseases, and ... fred waara trout unlimited banquet

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WebApr 1, 2024 · To date, the majority have focused on self-reported sleep duration, but in recent years genome-wide association studies of objectively-measured sleep have emerged. These genetic studies have discovered multiple common genetic variants and as such, have provided insight into potential biological pathways, causal relationships … WebMar 18, 2024 · After these exclusions, we searched for all remaining independent sleep-associated variants (149 for insomnia, 57 for total sleep duration [and an additional 25 and 71 variants for short and long habitual sleep duration, respectively] and 208 for chronotype) in the GWAS of NMR metabolomic measures, and the directions of the summary data … WebMar 7, 2024 · Sleep is essential for homeostasis and insufficient or excessive sleep are associated with adverse outcomes. Here, the … fred w875rx1

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WebDec 10, 2024 · Recent GWAS have also reported common variants that are associated with sleep duration in UK Biobank 10,11,12. However, GWAS of behavioural traits such as … WebFeb 24, 2024 · The instrumental variables of sleep duration were identified from the hitherto largest GWAS meta-analysis in individuals of European ancestry in the UK Biobank (Dashti et al., 2024), which have identified 78 SNPs associated with continuous sleep duration (n = 446,118), 27 SNPs associated with short sleep duration (<7 h; n = … fred wabbyWebAug 10, 2024 · At least three studies have shown involvement of hypocretin receptor type 2, known to be involved in alertness and also associated with sleep duration via GWAS study; 5-hydroxytrptamine (serotonin ... fred waara trout unlimited

"WebApr 1, 2024 · To date, the majority have focused on self-reported sleep duration, but in recent years genome-wide association studies of objectively-measured sleep have … " - Gwas sleep duration

Gwas sleep duration

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WebSep 12, 2024 · Sleep duration data were not available in ALSPAC, BiB or FinnGen, which all contributed to two-sample MR only (Fig. 1). Selection of genetic IVs for self-report sleep duration. Currently, nine GWAS of self-report sleep duration are available, with details in Additional file 1: Table S2 [2, 42,43,44,45,46,47,48,49,50,51]. WebMar 8, 2024 · The sites identified in this study showed consistent effects with a previous GWAS of more than 47,000 adults but limited consistency with another GWAS of sleep duration among more than 10,500 children …

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WebGWAS is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms GWAS - What does GWAS stand for? The Free Dictionary WebMar 7, 2024 · Genetic risk scores for sleep duration, short sleep and long sleep were tested using the weighted genetic risk score calculated by summing the products of the …

WebMar 7, 2024 · Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association … WebFeb 10, 2024 · A twin study estimated heritability of self-reported napping and objective daytime sleep duration to be 65% and 61%, ... to account for sleep apnea, GWAS excluding participants with diagnosed ...

WebAlthough some of the genes previously identified by the GWAS on individual sleep traits were not identified here, such as BAX8, BANK1 of sleep duration, 22 RGS16, RNASEL of chronotype, 19 DLEU7 of snoring, 19 AC095050.1 of dozing, 19 HEXIM2/LOC339192, CCDC68/TCF4 of insomnia, 23 more novel sleep-related genes were identified by using … WebA GWAS was performed in a Finnish sample (n = 1941), and variants with suggestive association (P < 5 × 10 −5) were tested in a follow-up sample from the same population with sleep duration (n = 6834) and time in bed (n = 1720). Variants with pointwise association of P < 0.05 in the follow-up sample were analysed further.

Web1160: Output from GWAS pipeline using Phesant derived variables from UKBiobank: Top 30 related datasets Info. ieu-a-1088: Sleep duration; ebi-a-GCST003839: Sleep duration; …

WebDec 19, 2016 · (encoding p.Pro385Arg) associated with short sleep duration has been identified and was confirmed in mouse models 0. Genome-wide asso-ciation studies … blinu coinmarketcapWebAug 5, 2016 · A subsequent GWAS meta-analysis including 47,180 individuals identified a single locus for sleep duration near PAX8 . Fifteen loci associated with chronotype were recently discovered by 23andMe [ … blintz or pierogi filling crosswordWebOct 30, 2024 · We considered GWAS for all sleep traits ascertained in UKB: sleep duration, 12 morning diurnal preference (also referred to as “chronotype”), 10 daytime napping frequency, 22 snoring, insomnia symptoms, 9 difficulty awakening, and daytime sleepiness 23 (phenotype definitions and GWAS procedures are provided in Data S1 … fred wachtelWebTwo SNPs were in KIF26B, which encodes the Kinesin Family Member 26 B. Kinesins are transporters of membranous organelles in mammalian neurons. 43 In a GWAS of sleep duration, KIF26B was reportedly associated with a short sleep duration of fewer than 6 hours. 44 In addition, Hautakangas et al performed a genome-wide meta-analysis of … blintz topping crosswordWebApr 6, 2024 · A GWAS for dichotomized sleep duration was performed to be consistent with our categorization strategy. IGAP meta-analysed GWAS datasets consisted of 21,982 Alzheimer’s disease ... fred wachterWebApr 1, 2024 · A GWAS is a hypothesis-free study in which the associations between millions of single nucleotide polymorphisms (SNPS – a type of common genetic variant present in … blintz topping crossword clueWebJan 6, 2024 · We conducted a genome-wide association study (GWAS) of sleep health score (overall assessment of sleep duration, snoring, insomnia, chronotype, and daytime dozing) using 336,463 participants from the UK Biobank. Proteome-wide association study (PWAS) and transcriptome-wide association study (TWAS) were then performed to … blintz souffle recipe food network