Mannitol bei cisplatin
WebSep 25, 2024 · Mannitol is a compound that has been thought to help negate cisplatin-induced nephrotoxicity. Mannitol is a diuretic, causing increased amount of urination, … WebOct 7, 2015 · Purpose The purpose of this study is to compare the incidence and severity of nephrotoxicity in patients receiving cisplatin with saline hydration vs. saline hydration with mannitol. Methods Retrospective chart review of all patients receiving a starting dose of cisplatin 100 mg/m2 with concurrent radiation for SCCHN between January 1, 2009 and …
Mannitol bei cisplatin
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WebJun 23, 2024 · The administration of mannitol or a diuretic is also required when the administrated cisplatin dose is higher than 60 mg/m 2 of body surface. It is necessary that the patient drinks large quantities of liquids for 24 hours after the cisplatin infusion to ensure adequate urine secretion. 4.3 Contraindications WebJun 27, 2016 · Background: Cisplatin-induced nephrotoxicity is a dose limiting adverse effect that occurs in nearly one-third of patients. Mannitol administration has been used as a means to negate this toxicity.
WebOct 8, 2024 · Zumindest bei höheren Cisplatin-Dosen ≥60 mg/m 2 erfolgt in den meisten Zentren eine prophylaktische Gabe von Mannitol (z. B. 125 ml 20 %ige Lösung vor der Cisplatin-Gabe). Eine Diuretika-Gabe bei inadäquater Hydrierung sollte aber in jedem Falle unterbleiben. Sie kann sogar zu einer Verschlechterung der Nierenfunktion führen. WebSpecifically, short-duration, low-volume, outpatient hydration with magnesium supplementation and mannitol forced diuresis (in select patients) represent best practice …
WebFeb 1, 1987 · Caring for the patient receiving cisplatin in the outpatient/ambulatory-care setting is a challenging nursing responsibility. Because of increased understanding regarding those factors that most influence nephrotoxicity and the application of creative hydration protocols, the administration of cisplatin in the outpatient area is both safe … WebAug 2, 2016 · Mannitol is an osmotic diuretic that increases urine output. It may be used before cisplatin to reduce the nephrotoxic effects of cisplatin. Not all institutions use …
WebBackground Cisplatin induced nephrotoxicity is a dose limiting adverse effect that occurs in nearly one-third of patients. Mannitol administration has been used as a means to negate this toxicity. Purpose The aim of this study was to evaluate the incidence of cisplatin induced nephrotoxicity in patients treated with and without mannitol. Specfically, the …
WebJan 31, 2012 · Mannitol plus hydration has been used for several years to alleviate toxicity associated with cisplatin therapy. However, the data for mannitol administration have … apurandomeWebNov 30, 2024 · Cisplatin 1mg/ml Injection BP Active Ingredient: cisplatin Company: Sandoz Limited See contact details ATC code: L01XA01 About Medicine Prescription only medicine Healthcare Professionals (SmPC) This information is for use by healthcare professionals Last updated on emc: 30 Nov 2024 Quick Links apu rangerWebFeb 5, 2024 · Patients were randomly assigned to either a mannitol 20 g intravenous single dose after cisplatin or a placebo (saline). The primary outcome was to compare acute kidney injury (AKI), which was defined as increase creatinine 0.3 mg/dl in 48 hours by KDIGO criteria using serum creatinine and 24 hour urine creatinine to calculated. Study … apurano warngauWebDec 16, 2024 · Conclusion: Current evidence revealed that mannitol was an effective and safe drug to reduce cisplatin-induced nephrotoxicity events, especially Grade 3 events. … apuraramWebJan 1, 2024 · There was a significantly smaller decrease in 51Cr-EDTA clearance in the mannitol group indicating a nephroprotective effect ofMannitol, which is used to protect the kidneys in head and neck cancer patients treated with cisplatin. Introduction: Cisplatin is used as treatment for several different malignancies and a well-known complication is … apurarWebJan 1, 1980 · Percent of Cisplatin Remaining as a Function of Time after Storage for 72 hr at 25°C and 4°C in 5% Dextrose Injection with 0.45% Sodium Chloride and 1.875% Mannitol a a All solutions were exposed to fluorescent lighting of 60 footcandles. All solutions were passed through an iv administration set. apu ranking qsWebAug 30, 2024 · Recent studies suggested that mannitol has a protective effect against cisplatin-induced nephrotoxicity for high-dose cisplatin used in head and neck cancer. … apurar das