2024 The carbon tetrachloride model in mice

The carbon tetrachloride model in mice

Author: ixpn

August undefined, 2024

網頁2010年7月9日 · The carbon tetrachloride (CCl4)-induced mouse model has been historically relied upon to study liver injury and regeneration. We exposed mice to CCl4 to … 網頁CCl 4 -induced mice also exhibited considerable increases of phosphorylation of nuclear factor-kappa B (NF-κB) p65 and pro-inflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).

Processes Free Full-Text Protective Effects of Chlorogenic Acid against Carbon Tetrachloride-Induced Hepatotoxicity in Mice

網頁2024年1月4日 · The effects of hypoxia inducible factor-2α (HIF-2α) deficiency on liver fibrosis have not been demonstrated in a fibrosis model induced by carbon tetrachloride (CCl 4 ). We aimed to examine whether hepatocyte-specific HIF-2α deletion could ameliorate CCl 4 -induced liver fibrosis in mice. Methods 網頁2024年11月26日 · This is the first study to investigate the hepatoprotective effect of CQ on acute liver injury caused by carbon tetrachloride (CCl4) in a murine model and the underlying molecular mechanisms. Ninety-six mice were randomly divided into the control (n = 8), CQ (n = 8), CCl4 (n = 40), and CCl4 + CQ (n = 40) treatment groups. subaru outback rally light bar

Chloroquine ameliorates carbon tetrachloride-induced acute liver …

網頁2024年12月24日 · Carbon tetrachloride (reagent grade, 99.9%), silymarin (≥95%), and CGA were acquired from the Sigma Chemical Co. (St. Louis, MO, USA). All the other analytical grade chemicals and reagents used in this study were received from local chemical companies. 2.2. Animals 網頁Carbon tetrachloride, also known by many other names (such as tetrachloromethane, also recognised by the IUPAC, carbon tet in the cleaning industry, Halon-104 in firefighting, and Refrigerant-10 in HVACR) is a chemical compound with the chemical formula CCl4. It is a colourless liquid with a "sweet" smell that can be detected at low levels. It ... 網頁Flow diagram depicting treatment of strain A/J mice with carbon tetrachloride (CCl4). (A) Schema. Mice were treated three times per week for 17 weeks by oral gavage with 0.04 cc of a 40%... pain in base of skull back

The carbon tetrachloride model in mice Semantic Scholar

Sci-Hub The carbon tetrachloride model in mice. Laboratory …

網頁2024年4月3日 · Background: The effects of hypoxia inducible factor-2α (HIF-2α) deficiency on liver fibrosis have not been demonstrated in a fibrosis model induced by carbon tetrachloride (CCl 4). We aimed to examine whether hepatocyte-specific HIF-2α deletion could ameliorate CCl 4 -induced liver fibrosis in mice. 網頁ABSTRACT We investigated the effects of carbon tetrachloride (CCl 4) exposure on liver detoxification.We confirmed that 0.2%-0.8% CCl 4 decreased the liver carboxylesterase … subaru outback rally armor mud flaps網頁The authors regret that an incorrect version of Fig. 3 was included in the original article. The correct version of Fig. 3 is presented below.(Figure Presented).The Royal Society of … pain in base of spine near tailbone

"網頁12. McLean, EK, McLean, AE, Sutton, PM. Instant cirrhosis. An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon … " - The carbon tetrachloride model in mice

The carbon tetrachloride model in mice

[PDF] Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice …

網頁2015年4月1日 · In the first section we focus on the carbon tetrachloride (CCl4) model in mice, which is the toxic model of liver fibrosis induction most commonly used … 網頁2024年11月26日 · This is the first study to investigate the hepatoprotective effect of CQ on acute liver injury caused by carbon tetrachloride (CCl 4) in a murine model and the underlying molecular...

Did you know?

網頁2024年9月25日 · This study evaluated the severity of liver fibrosis induction by intraperitoneal carbon tetrachloride (CCl 4) injections in mice. 29 male C57BL/6N mice … 網頁2024年12月24日 · The protective effects of chlorogenic acid (CGA) against liver injury were evaluated by its reduction in carbon tetrachloride (CCl4)-induced hepatic damage in …

網頁Carbon Tetrachloride (CCl 4 )-Induced Rodent Hepatic Injury Model The availability of appropriate experimental animal models is of prime importance to provide a better understanding of the pathogenesis of liver diseases and allow the development and evaluation of new therapeutic interventions. 網頁In the first section we focus on the carbon tetrachloride (CCl₄) model in mice, which is the toxic model of liver fibrosis induction most commonly used worldwide. Agid: 6239617 …

網頁2015年4月2日 · Experimental liver fibrosis in mice can be induced by surgical intervention (e.g. bile duct ligation), genetic manipulation of fibrosis-related genes (e.g. Mdr2 knockout … 網頁2024年6月14日 · In this study, we investigated the protective effects of hSAP against carbon tetrachloride (CCl 4 )-induced acute liver injury in mice, including hepatoprotective and anti-inflammatory effects in acute liver injury, as well as the potential of hSAP to inhibit the migration and activation of HSCs. Materials and methods hSAP

網頁In hepatocytes, carbon tetrachloride (CCl 4) is transformed into trichloromethyl free radicals that can trigger cell damage that can lead to hepatocellular injuries such as fibrosis and cirrhosis (Zhao et al., 2024a ), resulting in oxidative stress, inflammation, and pyroptosis (Otrubova et al., 2024 ).

網頁Phenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice. The mRNA expression levels of Cyp3a11 and Cyp2b10 in … subaru outback rally light bar 2021網頁Background: Several phyto-chemicals have been identified and suggested as potential therapeutic options for hepatotoxicity management. Objective: To assess the hepatoprotective effect of scopoletin, a pure phyto-chemical, in carbon tetrachloride (CCl 4)-induced hepatotoxicity model in Wistar rats. ... pain in base of spine when sitting網頁2024年4月3日 · Background The effects of hypoxia inducible factor-2α (HIF-2α) deficiency on liver fibrosis have not been demonstrated in a fibrosis model induced by carbon … subaru outback rally網頁2015年4月1日 · Comparing distress of mouse models for liver damage. This study used receiver operating characteristic curve analysis to quantify the performance of burrowing … subaru outback ratings網頁2024年5月1日 · To establish hepatocarcinogenesis mouse model, a single dose of 25 mg/kg DEN (N-Nitrosodiethylamine, BioChem Partner, China) was i.p injected into both female and male WT and HKO mice ( N = 8 each group) at 14 days of age, followed by administration of 10% CCl 4 (v/v in corn oil, 8 ml/kg of body weight, Solarbio, China) … subaru outback rear bushings網頁2024年5月1日 · Carbon tetrachloride CCl 4 is not a drug, but high doses (≥1 mL/kg) do cause reproducible acute liver injury that resembles intrinsic DILI. After APAP, CCl 4 is probably the most common model of xenobiotic-induced acute liver injury. subaru outback rattling noise網頁2024年4月9日 · Download Citation On Apr 9, 2024, Chieri Fujino and others published Attenuation of phenobarbital‐induced cytochrome P450 expression in carbon … subaru outback rally wheels