Web15. jún 2024 · FIGURE 1.Types of DPCs. Schematic depicting the four types of DPCs. (A) Type 1 DPCs are proteins crosslinked to unperturbed duplex DNA, generally induced by nonspecific agents.(B) Type 2 DPCs are crosslinked to the ends of SSBs and arise from abortive DNA repair processes.(C) Types 3 and 4 DPCs are abortive DNA-topoisomerase … Web24. okt 2024 · Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a …
Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes
WebA nick is a discontinuity in a double stranded DNA molecule where there is no phosphodiester bond between adjacent nucleotides of one strand typically through damage or enzyme action. Nicks allow DNA strands to untwist during replication, and are also thought to play a role in the DNA mismatch repair mechanisms that fix errors on both the … Web12. aug 2011 · Introduction. Base excision repair (BER) is the primary cellular mechanism to address DNA base damage, which results from both endogenous and exogenous agents such as reactive oxygen species, alkylating agents, and ionizing irradiation .Base damage is processed by DNA glycosylases and AP endonuclease into a single-strand break (SSB) … goochland free dental clinic
Homology-directed repair of DNA nicks via pathways distinct from ... - …
Web1. jan 2024 · DNA topoisomerase II (TOP2) enzymes achieve this by binding DNA and introducing an enzyme-bridged DNA double-strand break (DSB) where each protomer of … Web20. apr 2009 · The ability to interfere with topoisomerase II (TOP2) and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. Can recent studies lead to refined targeting of TOP2 ... WebTopoisomerase II (TOP2) resolves topologically entwined duplex DNA. It generates a transient DNA double-strand break intermediate, known as TOP2 cleavage complex … health food store tucson az